Blood management in older adults questioned

Published:

Geoff Simon in lab

USC-led research exploring blood management in older patients with anaemia and blood loss has raised questions around the current recommended medical care approach.

Lead author and USC academic Geoff Simon said current worldwide adult medical guidelines for blood transfusions are based mainly on data from people under the age of 65.

“Blood management in older adults who are sick is not something that has been widely studied and therefore a lot of the guidance for these patients uses a one-size-fits-all type approach,” Mr Simon said.

“Often this means that the restrictive, or lower, haemoglobin thresholds that guide blood use for people under 65 don’t work as well as they could for older patients,” he said.

“It is great to see that transfusion rates are going down in general as per blood management guidelines, but our research suggests that we could be managing things differently for better outcomes in older adults.”

Geoff Simon said anaemia is associated with worse outcomes in older adults, but the reasons are not well understood. The USC research has focussed on changes in oxygen delivery to the body with older age due to factors such as falling cardiac performance.

“Our research analysed the use of blood in older patients based on some international trials. We found that the older patients who were managed with haemoglobin levels around 100 g per litre had a lower mortality rate and had fewer cardiac complications than those managed around 70 or 80 g per litre,” Mr Simon said.

“We then reviewed further evidence to explore the biological reasons behind differences in transfusion trial outcomes related to haemoglobin thresholds in different age groups,” he said.

“Based on those findings the research team predicted that older adults require a haemoglobin of 100g per litre to achieve the same oxygen delivery potential as a younger patient with haemoglobin of 70g per litre.

“We believe this indicates the need for patient blood management guidance to be much more specific to older adults, and distinct from younger adults.

“It reinforces the need to conserve the patients’ blood and to investigate and treat the causes of anaemia in older adults, so they are better able to cope with physical demands.

 “This could offer much better outcomes to older patients with anaemia both in a hospital setting but also in community settings to better their quality of life.”

Impacts of Aging on Anaemia Tolerance, Transfusion Thresholds, and Patient Blood Management was recently published in international journal Transfusion Medicine Review and is listed at the top of the review’s articles with the most social media attention from 2017-2019.
 

 
Community Health & Wellness Science & Research University & TAFE
Social:   

University Of The Sunshine Coast : View Full Profile
90 Sippy Downs Drive, Sippy Downs
07 5430 1234
University Of The Sunshine Coast
Showing 10+ recent articles for this business
A design job at the Museum of Ice Cream? Sweet! 06 August 2020 | USC Design and Communication graduate Lilli Collingwood sank her teeth into a delectable new career in New York City early last year at the Museum of Ice Cream. More information...
Oldest Red-tailed Tropicbird found on reef island 05 August 2020 | USC researchers have found what could be the oldest known breeding individual of one of the world’s most elusive seabirds on Lady Elliot Island, at the southern end of the Great Barrier Reef. More information...
Graduate on cutting edge of respiratory testing in UK 04 August 2020 | USC Biomedical Science graduate Kellie Strickland had to pinch herself when she landed in England in September last year to take up a respiratory physiologist position at the Queen Alexandra Hospital in Portsmo... More information...
Identical twins cater to nutrition needs of Lightning 03 August 2020 | Identical twin sisters with USC Nutrition and Dietetics degrees are working to boost the power performances of Sunshine Coast Lightning players this season. More information...
USC research projects attract $2M in ARC funding 30 July 2020 | Associate Professor Sandy O’Sullivan will receive $1 million to study and map the complex identities of First Nations peoples; and Associate Professor Celine Frere will receive nearly $970,000 to help protect... More information...
High-tech skills give graduate winning edge 28 July 2020 | Specialising in geospatial science at university has helped a USC graduate gain a coveted award at a leading international design, engineering and science consultancy. More information...
USC’s new campus wins construction award 27 July 2020 | USC’s new state-of-the-art campus at Moreton Bay, which has attracted 1,800 students since opening in February, has just been recognised with a top construction award. More information...
Researchers gear up for cycling safety project 22 July 2020 | Research is now underway at USC that could lead to a much better understanding of the risks facing cyclists on our roads and what’s required to improve their safety. More information...
USC's prescribed burn postponed to 30 July 22 July 2020 | The prescribed burn planned for heathland at USC tomorrow (Thursday 23 July) has been postponed due to wet weather. More information...
Development endangers world’s largest mangrove forest 21 July 2020 | A scientist from USC Australia has raised concerns that the world’s largest mangrove forest – the Sundarbans in Bangladesh – could be under threat from a major development. More information...


comments powered by Disqus

All articles submitted by third parties or written by My Sunshine Coast come under our Disclaimer / Terms of Service